SPAG8

Across TCGA patient cohorts, SPAG8 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG8-associated genes across cancer lineages are INPP4B, Notch1, and A-Raf_pS299. Each is linked with SPAG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG8-to-partner and partner-to-SPAG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SPAG8-low versus SPAG8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG8→partner) and Y-score (partner→SPAG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.476	-3.794	.001	<.001	3	2
UCEC	Notch1 →	+0.211	+2.335	<.001	.018	3	2
UCEC	A-Raf_pS299 →	-0.192	-3.321	<.001	.010	3	1
UCEC	ETS-1 →	+0.346	+3.321	.015	.010	3	1
UCEC	FoxM1 →	+0.298	+2.700	.010	.006	3	1
UCEC	GATA3 →	+0.210	+2.013	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

INPP4B by SPAG8 expression — UCEC

Explore this box plot interactively →