SPAG8

Across TCGA pan-cancer cohorts, SPAG8 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SPAG8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SPAG8 RNA is repressed in tumor relative to normal tissue. In most cancer types SPAG8 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and BLCA are the cancer types where SPAG8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAG8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.558	<.001	9	view →
LUSC	Female	II,III,IV	−1.468	<.001	8	view →
BLCA	Male	IV	−1.362	<.001	8	view →
KICH	Female	All	−0.853	<.001	8	view →
LIHC	All	II,III,IV	+0.347	<.001	7	view →
BRCA	Female	All	−0.324	<.001	6	view →
UCEC	All	All	−1.231	.004	4	view →
STAD	All	All	−0.366	.013	3	view →
CHOL	All	All	+1.028	<.001	2	view →
PRAD	All	All	−0.249	.001	2	view →
KIRC	All	All	+0.121	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SPAG8–LUAD

Open the LUAD breakdown →