SPAG8

Across TCGA patient cohorts, SPAG8 mutation is significantly associated with the RNA expression of many other genes, with 2,568 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAG8-associated genes across cancer lineages are TBR1, MTND5P22, and SNORD82. Each is linked with SPAG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAG8-to-partner and partner-to-SPAG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBR1 grouped by SPAG8-low versus SPAG8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG8→partner) and Y-score (partner→SPAG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TBR1 →	+0.352	+3.932	<.001	.004	3	2
PRAD	MTND5P22 →	+0.604	+7.939	<.001	.008	3	2
LIHC	SNORD82 →	+0.630	+5.447	<.001	.005	3	2
LIHC	RNA5SP293 →	+0.340	+8.503	<.001	<.001	3	2
UCEC	RNU4-58P →	+0.247	+2.870	<.001	.001	3	2
UCEC	IGHD3-10 →	+1.140	+2.196	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,568 associations by consensus.

TBR1 by SPAG8 expression — COAD

Explore this box plot interactively →