SPAG8

Across TCGA patient cohorts, SPAG8 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,890 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPAG8-associated proteins across cancer lineages are LZTFL1, IFT122, and IFT140. Each is linked with SPAG8 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPAG8-to-partner and partner-to-SPAG8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPAG8 versus LZTFL1 in BRCA, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAG8→partner) and Y-score (partner→SPAG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LZTFL1 →	+0.595	+0.748	<.001	<.001	3	7
BRCA	IFT122 →	+0.432	+0.860	<.001	<.001	3	7
BRCA	IFT140 →	+0.530	+0.732	<.001	<.001	3	7
UCEC	TPPP3 →	+1.655	+1.637	<.001	<.001	3	6
UCEC	OSCP1 →	+0.634	+1.743	<.001	<.001	3	6
UCEC	IFT22 →	+0.459	+1.653	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,890 associations by consensus.

SPAG8 vs LZTFL1 — BRCA

Explore this scatter interactively →