sterol O-acyltransferase 1Genealiases: ACACT · ACAT · ACAT-1 · ACAT1 · SOAT · STAT
Q-omics provides the consensus-scored SOAT1 profile across patient tissues and cancer cell-line models. SOAT1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, SOAT1 is differentially expressed in 15, with the highest sampling consensus in KIRP. Additionally, SOAT1 protein abundance shows 22,458 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight UVM, KIRP, and PDAC as cancer lineages where SOAT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SOAT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SOAT1 survival associations across molecular data types. SOAT1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (5) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SOAT1 RNA expression–survival associations across cancer types. High SOAT1 expression shows unfavorable associations in UVM, MESO, STAD, ACC, LGG and CESC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for SOAT1 RNA expression.
This table summarizes SOAT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 9. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SOAT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SOAT1 shows higher tumor expression in KIRP, BLCA, KIRC, HNSC, STAD and LIHC. The KIRP box plot shows higher SOAT1 RNA expression in tumor versus normal tissue (log2 FC = +1.320, t-test p < 0.001).
This table shows molecular features associated with SOAT1 in patient tissues and cancer cell lines. In patient samples, SOAT1 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, SOAT1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BLOOD_Leukemia.
