SOAT1

Across TCGA patient cohorts, SOAT1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOAT1-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and EGFR. Each is linked with SOAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOAT1-to-partner and partner-to-SOAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SOAT1-low versus SOAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOAT1→partner) and Y-score (partner→SOAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.302	+2.415	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.606	+1.906	.011	.016	3	2
UCEC	EGFR →	-0.212	-2.321	<.001	.034	3	1
UCEC	eIF4E →	+0.218	+3.087	.010	<.001	3	1
UCEC	FASN →	+0.430	+3.459	.006	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.105	.008	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

PCNA by SOAT1 expression — UCEC

Explore this box plot interactively →