SOAT1

Across TCGA pan-cancer cohorts, SOAT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SOAT1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SOAT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SOAT1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

UVM, MESO, and STAD are the cancer types where SOAT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	III,IV	0.267	1.000	<.001	86	view →
MESO	OS	Tertile	All	0.159	0.399	.004	73	view →
STAD	OS	Median	All	0.600	0.852	<.001	67	view →
ACC	DFS	Median	All	0.380	0.787	<.001	52	view →
LGG	OS	Median	All	0.375	0.534	<.001	49	view →
CESC	DFS	Tertile	All	0.754	0.878	.005	38	view →
LIHC	OS	Quartile	All	0.676	0.893	<.001	37	view →
BLCA	DFS	Quartile	II,III,IV	0.442	0.567	.013	20	view →
LUAD	DFS	Median	IV	0.775	0.214	.003	16	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	12	view →
PRAD	DFS	Tertile	All	0.945	0.852	.003	12	view →
UCEC	DFS	Tertile	III,IV	0.705	0.505	.025	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SOAT1–UVM (OS)

Open the UVM breakdown →