Q-omics provides the consensus-scored SLC35A4 profile across patient tissues and cancer cell-line models. SLC35A4 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, SLC35A4 is differentially expressed in 14, with the highest sampling consensus in THCA. Additionally, SLC35A4 RNA expression shows 18,632 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight MESO, THCA, and ACC as cancer lineages where SLC35A4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SLC35A4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SLC35A4 survival associations across molecular data types. SLC35A4 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (6) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SLC35A4 RNA expression–survival associations across cancer types. High SLC35A4 expression shows unfavorable associations in UVM, LIHC and LUAD, but favorable associations in MESO, READ and KIRC. The MESO Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for SLC35A4 RNA expression.
This table summarizes SLC35A4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for SLC35A4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SLC35A4 shows lower tumor expression in THCA, KICH and LUSC and higher tumor expression in LIHC, KIRC and KIRP. The THCA box plot shows higher SLC35A4 RNA expression in normal versus tumor tissue (log2 FC = −0.884, t-test p < 0.001).
This table shows molecular features associated with SLC35A4 in patient tissues and cancer cell lines. In patient samples, SLC35A4 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, SLC35A4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and UPPER_AERODIGESTIVE_TRACT.
