Q-omics provides the consensus-scored SF3B4 profile across patient tissues and cancer cell-line models. SF3B4 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, SF3B4 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, SF3B4 protein abundance shows 32,894 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, HNSC, and LSCC as cancer lineages where SF3B4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SF3B4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SF3B4 survival associations across molecular data types. SF3B4 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (5) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SF3B4 RNA expression–survival associations across cancer types. High SF3B4 expression shows unfavorable associations in ACC, KIRP, LIHC, KIRC and MESO, but favorable associations in LUSC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for SF3B4 RNA expression.
This table summarizes SF3B4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for SF3B4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SF3B4 shows higher tumor expression in HNSC, COAD, LIHC, LUSC, LUAD and STAD. The HNSC box plot shows higher SF3B4 RNA expression in tumor versus normal tissue (log2 FC = +1.198, t-test p < 0.001).
This table shows molecular features associated with SF3B4 in patient tissues and cancer cell lines. In patient samples, SF3B4 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SF3B4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BLOOD_Leukemia.
