SF3B4

Across TCGA patient cohorts, SF3B4 mutation is significantly associated with the RNA expression of many other genes, with 793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B4-associated genes across cancer lineages are SNORD114-28, LARP1BP2, and MTCYBP23. Each is linked with SF3B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B4-to-partner and partner-to-SF3B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-28 grouped by SF3B4-low versus SF3B4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B4→partner) and Y-score (partner→SF3B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNORD114-28 →	+0.471	+4.136	<.001	.008	3	2
COAD	LARP1BP2 →	+0.263	+3.546	<.001	.004	3	2
COAD	MTCYBP23 →	+0.366	+3.285	<.001	.003	3	2
UCEC	FAM126B →	+0.418	+3.212	.007	.009	3	2
UCEC	RBM15 →	+0.567	+3.338	<.001	.005	3	2
UCEC	GPR137B →	+0.714	+3.343	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 793 associations by consensus.

SNORD114-28 by SF3B4 expression — COAD

Explore this box plot interactively →