SF3B4

Across TCGA cell cohorts, SF3B4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,526 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SF3B4-associated GO terms across cancer lineages are Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11), U2-type prespliceosome assembly, and Negative regulation of DNA-templated DNA replication. Each is linked with SF3B4 in more than 13 cancer types. Because this analysis shows association rather than direction, both SF3B4-to-partner and partner-to-SF3B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) grouped by SF3B4-low versus SF3B4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B4→partner) and Y-score (partner→SF3B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.106	+1.031	<.001	<.001	3	14
SKIN	U2-type prespliceosome assembly →	+0.095	+0.769	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated DNA replication →	+0.120	+0.816	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Spliceosomal snRNP assembly →	+0.113	+1.043	<.001	<.001	3	13
URINARY_TRACT	Regulation of protein sumoylation →	+0.142	+0.833	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.186	+0.761	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,526 associations by consensus.

Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) by SF3B4 expression — BREAST

Explore this box plot interactively →