SF3B4

Across TCGA patient cohorts, SF3B4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF3B4-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and JNK_pT183_Y185. Each is linked with SF3B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B4-to-partner and partner-to-SF3B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SF3B4-low versus SF3B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B4→partner) and Y-score (partner→SF3B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.775	+3.019	.006	.019	3	2
UCEC	A-Raf_pS299 →	-0.165	-3.000	.004	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-3.571	.015	.002	3	1
UCEC	Ku80 →	+0.277	+2.472	.015	.011	3	1
UCEC	ATM →	-0.571	-3.584	.009	.002	3	1
UCEC	Caspase-8 →	-0.272	-2.459	.025	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Caspase-7-cleavedD198 by SF3B4 expression — UCEC

Explore this box plot interactively →