SF3B4

Across TCGA patient cohorts, SF3B4 protein abundance is significantly associated with the RNA expression of many other genes, with 15,582 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SF3B4-associated genes across cancer lineages are DKC1, MRPL9, and SEPTIN4. Each is linked with SF3B4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SF3B4-to-partner and partner-to-SF3B4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SF3B4 versus DKC1 in HNSC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B4→partner) and Y-score (partner→SF3B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DKC1 →	+0.635	+0.364	.004	.001	3	6
BRCA	MRPL9 →	+0.550	+0.414	<.001	<.001	3	6
GBM	SEPTIN4 →	-0.870	-0.297	<.001	<.001	3	6
COAD	SPOCK1 →	-1.211	-0.324	<.001	<.001	3	6
BRCA	HPGDS →	-0.639	-0.250	<.001	<.001	3	6
BRCA	FOLR2 →	-1.211	-0.329	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,582 associations by consensus.

SF3B4 vs DKC1 — HNSC

Explore this scatter interactively →