SF3B4

Across TCGA cell cohorts, SF3B4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SF3B4-associated genes across cancer lineages are MSGN1, TFDP3, and TAFA1. Each is linked with SF3B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF3B4-to-partner and partner-to-SF3B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by SF3B4-low versus SF3B4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF3B4→partner) and Y-score (partner→SF3B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TFDP3 →	+0.031	+3.196	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.176	+3.155	<.001	.008	3	1
LARGE_INTESTINE	CENPVL1 →	+0.150	+3.510	<.001	.003	3	1
LARGE_INTESTINE	OR5V1 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MSGN1 by SF3B4 expression — LARGE_INTESTINE

Explore this box plot interactively →