signal peptide, CUB domain and EGF like domain containing 3Genealiases: CEGF3 · SSFSC2
Q-omics provides the consensus-scored SCUBE3 profile across patient tissues and cancer cell-line models. SCUBE3 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, SCUBE3 is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, SCUBE3 RNA expression shows 18,941 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRP, KIRC, and THYM as cancer lineages where SCUBE3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SCUBE3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SCUBE3 survival associations across molecular data types. SCUBE3 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (4) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SCUBE3 RNA expression–survival associations across cancer types. High SCUBE3 expression shows unfavorable associations in KIRP, UVM, BLCA, SKCM, UCEC and HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for SCUBE3 RNA expression.
This table summarizes SCUBE3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SCUBE3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SCUBE3 shows lower tumor expression in KIRC, THCA, KIRP and KICH and higher tumor expression in HNSC and BRCA. The KIRC box plot shows higher SCUBE3 RNA expression in normal versus tumor tissue (log2 FC = −1.031, t-test p < 0.001).
This table shows molecular features associated with SCUBE3 in patient tissues and cancer cell lines. In patient samples, SCUBE3 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, SCUBE3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
