SCUBE3

Across TCGA cell cohorts, SCUBE3 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCUBE3-associated genes across cancer lineages are SAXO1, FBXW10, and REG3G. Each is linked with SCUBE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCUBE3-to-partner and partner-to-SCUBE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAXO1 grouped by SCUBE3-low versus SCUBE3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE3→partner) and Y-score (partner→SCUBE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SAXO1 →	+0.058	+3.781	<.001	.002	3	2
BLOOD_Leukemia	FBXW10 →	+0.039	+3.540	.001	.005	3	2
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	1
BLOOD_Lymphoma	KRTAP2-1 →	+0.085	+5.643	<.001	.002	3	1
OVARY	LCE1C →	+0.058	+5.196	<.001	.005	3	1
OVARY	KRTAP4-5 →	+0.086	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

SAXO1 by SCUBE3 expression — BLOOD_Leukemia

Explore this box plot interactively →