SCUBE3

Across TCGA patient cohorts, SCUBE3 mutation is significantly associated with the RNA expression of many other genes, with 2,819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCUBE3-associated genes across cancer lineages are SLC19A3, TMEM200C, and CHAF1A. Each is linked with SCUBE3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SCUBE3-to-partner and partner-to-SCUBE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC19A3 grouped by SCUBE3-low versus SCUBE3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE3→partner) and Y-score (partner→SCUBE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SLC19A3 →	-0.837	-3.564	.007	.002	3	4
UCEC	TMEM200C →	-0.491	-2.836	<.001	<.001	3	4
UCEC	CHAF1A →	+0.520	+1.665	<.001	.002	3	4
UCEC	NDUFA6 →	+0.545	+1.903	<.001	<.001	3	3
SKCM	TSPY26P →	-0.992	-2.887	.002	.001	3	3
COAD	RPARP-AS1 →	+0.439	+3.877	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,819 associations by consensus.

SLC19A3 by SCUBE3 expression — COAD

Explore this box plot interactively →