SCUBE3

Across TCGA cell cohorts, SCUBE3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,030 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCUBE3-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Regulation of myoblast fusion. Each is linked with SCUBE3 in more than 11 cancer types. Because this analysis shows association rather than direction, both SCUBE3-to-partner and partner-to-SCUBE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by SCUBE3-low versus SCUBE3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE3→partner) and Y-score (partner→SCUBE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.108	+0.976	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of myoblast fusion →	+0.102	+1.268	<.001	.001	2	12
OESOPHAGUS	Regulation of myoblast fusion →	+0.108	+0.533	<.001	.002	3	10
URINARY_TRACT	Regulation of DNA repair →	+0.051	+0.681	.001	.001	3	10
SOFT_TISSUE	Vacuole organization →	+0.034	+1.118	.001	<.001	2	11
LUNG_SCLC	Regulation of stem cell population maintenance →	+0.079	+0.821	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,030 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by SCUBE3 expression — LUNG_SCLC

Explore this box plot interactively →