SCUBE3

Across TCGA patient cohorts, SCUBE3 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCUBE3-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and MEK1. Each is linked with SCUBE3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SCUBE3-to-partner and partner-to-SCUBE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SCUBE3-low versus SCUBE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE3→partner) and Y-score (partner→SCUBE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.249	+1.936	.005	.008	3	4
STAD	Cyclin-B1 →	+0.644	+3.000	.007	.036	3	3
UCEC	MEK1 →	+0.459	+3.247	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.961	+3.186	.001	.009	3	3
STAD	TFRC →	+0.665	+3.000	.039	.036	3	2
COAD	PKC-a_pS657 →	-0.348	-2.304	.004	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

4E-BP1 by SCUBE3 expression — UCEC

Explore this box plot interactively →