salvador family WW domain containing protein 1Genealiases: SAV · WW45 · WWP4
Q-omics provides the consensus-scored SAV1 profile across patient tissues and cancer cell-line models. SAV1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, SAV1 is differentially expressed in 8, with the highest sampling consensus in KIRC. Additionally, SAV1 RNA expression shows 20,013 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BRCA, KIRC, and THYM as cancer lineages where SAV1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SAV1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SAV1 survival associations across molecular data types. SAV1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (3) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SAV1 RNA expression–survival associations across cancer types. High SAV1 expression shows unfavorable associations in BLCA, PAAD and ACC, but favorable associations in BRCA, KIRC and SKCM. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify BRCA as the clearest survival context for SAV1 RNA expression.
This table summarizes SAV1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for SAV1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SAV1 shows lower tumor expression in KIRC, BRCA, LUAD and UCEC and higher tumor expression in HNSC and CHOL. The KIRC box plot shows higher SAV1 RNA expression in normal versus tumor tissue (log2 FC = −0.679, t-test p < 0.001).
This table shows molecular features associated with SAV1 in patient tissues and cancer cell lines. In patient samples, SAV1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, SAV1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and UPPER_AERODIGESTIVE_TRACT.
