SAV1

Across TCGA pan-cancer cohorts, SAV1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SAV1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SAV1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SAV1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where SAV1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.905	0.356	.003	14	view →
CCRCC	OS	Median	All	1.000	0.680	.029	7	view →
LUAD	DFS	Median	III,IV	0.595	0.886	.014	6	view →
HNSC	DFS	Tertile	III,IV	1.000	0.921	.033	2	view →
LSCC	OS	Tertile	II,III,IV	0.892	0.594	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SAV1–PDAC (DFS)

Open the PDAC breakdown →