SAV1

Across TCGA pan-cancer cohorts, SAV1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SAV1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SAV1 RNA is repressed in tumor relative to normal tissue. In most cancer types SAV1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and BRCA are the cancer types where SAV1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAV1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.679	<.001	12	view →
HNSC	All	III,IV	+0.723	<.001	10	view →
BRCA	All	III,IV	−0.858	<.001	6	view →
CHOL	Male	All	+0.906	.001	4	view →
LUAD	Female	III,IV	−0.336	.032	3	view →
UCEC	All	All	−0.580	.002	2	view →
KIRP	Male	All	−0.351	.008	2	view →
COAD	All	II,III,IV	+0.348	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SAV1–KIRC

Open the KIRC breakdown →