SAV1

Across TCGA patient cohorts, SAV1 mutation is significantly associated with the RNA expression of many other genes, with 2,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAV1-associated genes across cancer lineages are LINC01941, CNGA2, and OR6Y1. Each is linked with SAV1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SAV1-to-partner and partner-to-SAV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01941 grouped by SAV1-low versus SAV1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAV1→partner) and Y-score (partner→SAV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01941 →	+0.175	+5.254	<.001	<.001	3	3
KIRP	CNGA2 →	+0.031	+4.628	<.001	.007	3	2
KIRP	OR6Y1 →	+0.072	+4.770	<.001	.006	3	2
KIRP	MIR495 →	+0.646	+5.301	<.001	.003	3	2
KIRP	SAPCD2P1 →	+0.034	+4.628	.001	.007	3	2
KIRP	FTLP18 →	+0.067	+7.134	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,076 associations by consensus.

LINC01941 by SAV1 expression — CESC

Explore this box plot interactively →