RB binding protein 7, chromatin remodeling factorGenealiases: RbAp46 · SPGFX9
Q-omics provides the consensus-scored RBBP7 profile across patient tissues and cancer cell-line models. RBBP7 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, RBBP7 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, RBBP7 protein abundance shows 37,814 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight LIHC, COAD, and LSCC as cancer lineages where RBBP7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RBBP7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RBBP7 survival associations across molecular data types. RBBP7 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (1) and mass-spec protein abundance (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RBBP7 RNA expression–survival associations across cancer types. High RBBP7 expression shows unfavorable associations in LIHC, LUAD, KIRP and KICH, but favorable associations in LUSC and KIRC. The LIHC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LIHC as the clearest survival context for RBBP7 RNA expression.
This table summarizes RBBP7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 9. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for RBBP7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RBBP7 shows higher tumor expression in COAD, HNSC, LIHC, LUSC, LUAD and KIRP. The COAD box plot shows higher RBBP7 RNA expression in tumor versus normal tissue (log2 FC = +0.926, t-test p < 0.001).
This table shows molecular features associated with RBBP7 in patient tissues and cancer cell lines. In patient samples, RBBP7 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, RBBP7 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BLOOD_Lymphoma.
