POU class 3 homeobox 3Genealiases: BRN1 · OTF8 · SNIBFIS · brain-1 · oct-8
Q-omics provides the consensus-scored POU3F3 profile across patient tissues and cancer cell-line models. POU3F3 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, POU3F3 is differentially expressed in 9, with the highest sampling consensus in COAD. Additionally, POU3F3 RNA expression shows 15,124 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight UVM, COAD, and KIRP as cancer lineages where POU3F3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for POU3F3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes POU3F3 survival associations across molecular data types. POU3F3 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (1) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible POU3F3 RNA expression–survival associations across cancer types. High POU3F3 expression shows unfavorable associations in UVM, COAD, UCEC and LGG, but favorable associations in BLCA and KIRC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for POU3F3 RNA expression.
This table summarizes POU3F3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for POU3F3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. POU3F3 shows lower tumor expression in COAD, KICH, BRCA, READ and PRAD and higher tumor expression in KIRP. The COAD box plot shows higher POU3F3 RNA expression in normal versus tumor tissue (log2 FC = −0.387, t-test p < 0.001).
This table shows molecular features associated with POU3F3 in patient tissues and cancer cell lines. In patient samples, POU3F3 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, POU3F3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BLOOD_Leukemia.
