Across TCGA pan-cancer cohorts, POU3F3 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated POU3F3 data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POU3F3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POU3F3 expression acts as an unfavorable survival marker.

HNSC are the cancer types where POU3F3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.176	0.639	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: POU3F3 tumor-vs-normal RNA expression · all POU3F3 data types