Across TCGA cell cohorts, POU3F3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU3F3-associated genes across cancer lineages are CCER1, DPRX, and HTN3. Each is linked with POU3F3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU3F3-to-partner and partner-to-POU3F3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU3F3→partner) and Y-score (partner→POU3F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCER1 →	+0.012	+4.754	<.001	.005	3	1
CNS	DPRX →	+0.050	+4.321	<.001	.009	3	1
CNS	HTN3 →	+0.998	+4.169	<.001	.008	3	1
LARGE_INTESTINE	C1QL2 →	+0.005	+4.099	.002	<.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.170	+4.155	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

POU3F3 survival (RNA) · tumor vs normal (RNA) · all POU3F3 data types