phorbol-12-myristate-13-acetate-induced protein 1Genealiases: APR · NOXA
Q-omics provides the consensus-scored PMAIP1 profile across patient tissues and cancer cell-line models. PMAIP1 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, PMAIP1 is differentially expressed in 15, with the highest sampling consensus in LUAD. Additionally, PMAIP1 RNA expression shows 18,081 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, LUAD, and UVM as cancer lineages where PMAIP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PMAIP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PMAIP1 survival associations across molecular data types. PMAIP1 RNA expression shows survival associations in the most cancer types (28), followed by mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PMAIP1 RNA expression–survival associations across cancer types. High PMAIP1 expression shows unfavorable associations in KIRP, KIRC, MESO, LIHC and PAAD, but favorable associations in BRCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for PMAIP1 RNA expression.
This table summarizes PMAIP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 2. The strongest signals are observed in LUAD for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for PMAIP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PMAIP1 shows higher tumor expression in LUAD, COAD, THCA, STAD, LUSC and READ. The LUAD box plot shows higher PMAIP1 RNA expression in tumor versus normal tissue (log2 FC = +1.904, t-test p < 0.001).
This table shows molecular features associated with PMAIP1 in patient tissues and cancer cell lines. In patient samples, PMAIP1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, PMAIP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BREAST.
