PMAIP1

Across TCGA patient cohorts, PMAIP1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMAIP1-associated genes across cancer lineages are EEF1E1-BLOC1S5, PEDS1-UBE2V1, and MT1CP. Each is linked with PMAIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMAIP1-to-partner and partner-to-PMAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by PMAIP1-low versus PMAIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMAIP1→partner) and Y-score (partner→PMAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EEF1E1-BLOC1S5 →	+0.071	+4.868	<.001	.004	3	1
UCEC	PEDS1-UBE2V1 →	+0.046	+3.943	.001	.007	3	1
UCEC	MT1CP →	+0.420	+3.871	<.001	.006	3	1
UCEC	RPL22P14 →	+0.242	+4.109	<.001	.004	3	1
UCEC	RPL21P91 →	+0.171	+3.969	.004	.005	3	1
UCEC	PPIAP32 →	+0.267	+3.847	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EEF1E1-BLOC1S5 by PMAIP1 expression — UCEC

Explore this box plot interactively →