PMAIP1

Across TCGA pan-cancer cohorts, PMAIP1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PMAIP1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PMAIP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PMAIP1 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.

LUAD, COAD, and THCA are the cancer types where PMAIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PMAIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+1.904	<.001	11	view →
COAD	Female	II,III,IV	+1.880	<.001	11	view →
THCA	Male	II,III,IV	+1.993	<.001	10	view →
STAD	All	II,III,IV	+1.312	<.001	8	view →
LUSC	Male	All	+2.283	<.001	7	view →
READ	All	All	+1.969	<.001	7	view →
UCEC	All	All	+1.811	<.001	6	view →
BRCA	All	III,IV	+1.533	<.001	6	view →
HNSC	Male	All	+1.009	<.001	6	view →
CHOL	All	All	+2.835	<.001	3	view →
ESCA	Male	All	+1.322	.022	2	view →
KICH	All	All	+1.096	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PMAIP1–LUAD

Open the LUAD breakdown →