PMAIP1

Across TCGA cell cohorts, PMAIP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,345 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PMAIP1-associated GO terms across cancer lineages are Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, Negative regulation of mitochondrial membrane potential, and Negative regulation of protein modification process. Each is linked with PMAIP1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PMAIP1-to-partner and partner-to-PMAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors grouped by PMAIP1-low versus PMAIP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMAIP1→partner) and Y-score (partner→PMAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+1.077	+2.715	.002	<.001	3	17
LIVER	Negative regulation of mitochondrial membrane potential →	+0.320	+2.903	<.001	<.001	3	12
STOMACH	Negative regulation of protein modification process →	+0.043	+1.883	<.001	.001	3	12
LIVER	Negative regulation of membrane potential →	+0.320	+2.903	<.001	<.001	3	12
PANCREAS	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.143	+1.988	<.001	<.001	3	11
SOFT_TISSUE	Regulation of protein modification by small protein conjugation or removal →	+0.062	+2.474	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,345 associations by consensus.

Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors by PMAIP1 expression — BONE

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