protein disulfide isomerase family A member 4Genealiases: ERP70 · ERP72 · ERp-72
Q-omics provides the consensus-scored PDIA4 profile across patient tissues and cancer cell-line models. PDIA4 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, PDIA4 is differentially expressed in 17, with the highest sampling consensus in HNSC. Additionally, PDIA4 protein abundance shows 23,406 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRP, HNSC, and GBM as cancer lineages where PDIA4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PDIA4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PDIA4 survival associations across molecular data types. PDIA4 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (6) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PDIA4 RNA expression–survival associations across cancer types. High PDIA4 expression shows unfavorable associations in KIRP, ACC, UVM, CESC and LGG, but favorable associations in OV. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRP as the clearest survival context for PDIA4 RNA expression.
This table summarizes PDIA4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for PDIA4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PDIA4 shows higher tumor expression in HNSC, KIRC, BLCA, COAD, LUAD and KIRP. The HNSC box plot shows higher PDIA4 RNA expression in tumor versus normal tissue (log2 FC = +1.949, t-test p < 0.001).
This table shows molecular features associated with PDIA4 in patient tissues and cancer cell lines. In patient samples, PDIA4 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, PDIA4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and CNS.
