PDIA4

Across TCGA cell cohorts, PDIA4 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PDIA4-associated genes across cancer lineages are TMSB4Y, MMD2, and OR10H5. Each is linked with PDIA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDIA4-to-partner and partner-to-PDIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMSB4Y grouped by PDIA4-low versus PDIA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA4→partner) and Y-score (partner→PDIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMSB4Y →	+1.284	+3.819	<.001	.001	3	2
BLOOD_Lymphoma	MMD2 →	+0.036	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR10H5 →	+0.112	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	ODF4 →	+0.124	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	RNASE9 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CT47B1 →	+0.307	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TMSB4Y by PDIA4 expression — LARGE_INTESTINE

Explore this box plot interactively →