Q-omics provides the consensus-scored OTOS profile across patient tissues and cancer cell-line models. OTOS expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, OTOS is differentially expressed in 6, with the highest sampling consensus in THCA. Additionally, OTOS RNA expression shows 9,009 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight COAD, THCA, and TGCT as cancer lineages where OTOS shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OTOS — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OTOS survival associations across molecular data types. OTOS RNA expression shows survival associations in the most cancer types (20), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OTOS RNA expression–survival associations across cancer types. High OTOS expression shows unfavorable associations in COAD, STAD, MESO, LGG and SARC, but favorable associations in ESCA. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify COAD as the clearest survival context for OTOS RNA expression.
This table summarizes OTOS tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for OTOS. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OTOS shows lower tumor expression in THCA and KICH and higher tumor expression in LUAD, LUSC, UCEC and HNSC. The THCA box plot shows higher OTOS RNA expression in normal versus tumor tissue (log2 FC = −4.990, t-test p < 0.001).
This table shows molecular features associated with OTOS in patient tissues and cancer cell lines. In patient samples, OTOS shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, OTOS RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and BONE.
