OTOS

Across TCGA pan-cancer cohorts, OTOS Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OTOS data layer compared with 20 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher OTOS Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTOS expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

CESC, COAD, and SKCM are the cancer types where OTOS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.047	0.875	<.001	24	view →
COAD	DFS	Median	All	0.248	0.691	.018	12	view →
SKCM	DFS	Median	III,IV	0.652	0.239	.023	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OTOS–CESC (OS)

Open the CESC breakdown →