OTOS

Across TCGA pan-cancer cohorts, OTOS RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of OTOS’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OTOS RNA is repressed in tumor relative to normal tissue. In most cancer types OTOS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where OTOS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTOS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−4.990	<.001	11	view →
KICH	All	II,III,IV	−0.220	.002	5	view →
LUAD	All	All	+0.136	.002	5	view →
LUSC	All	All	+0.107	.002	3	view →
UCEC	All	All	+0.782	.024	2	view →
HNSC	All	All	+0.148	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

OTOS–THCA

Open the THCA breakdown →