OTOS

Across TCGA cell cohorts, OTOS RNA expression is significantly associated with the go_rna of many other GO terms, with 517 significant associations in total. BONE shows the largest number of these associations.

The most reproducible OTOS-associated GO terms across cancer lineages are Regulation of calcineurin-NFAT signaling cascade, Regulation of calcineurin-mediated signaling, and Serotonin uptake. Each is linked with OTOS in more than 3 cancer types. Because this analysis shows association rather than direction, both OTOS-to-partner and partner-to-OTOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of calcineurin-NFAT signaling cascade grouped by OTOS-low versus OTOS-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOS→partner) and Y-score (partner→OTOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of calcineurin-NFAT signaling cascade →	+0.138	+0.051	<.001	<.001	3	4
SOFT_TISSUE	Regulation of calcineurin-mediated signaling →	+0.143	+0.051	<.001	<.001	3	4
BONE	Serotonin uptake →	-1.053	-0.042	.003	.001	3	3
SOFT_TISSUE	Epithelium migration →	-0.067	-0.043	.006	.009	3	3
SOFT_TISSUE	Negative regulation of platelet aggregation →	+0.143	+0.042	<.001	.003	3	3
SOFT_TISSUE	Neuroligin clustering involved in postsynaptic membrane assembly →	+1.100	+0.050	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 517 associations by consensus.

Regulation of calcineurin-NFAT signaling cascade by OTOS expression — SOFT_TISSUE

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