OTOS

Across TCGA patient cohorts, OTOS mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OTOS-associated genes across cancer lineages are RN7SL104P, FAM242E, and RNA5SP361. Each is linked with OTOS in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOS-to-partner and partner-to-OTOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL104P grouped by OTOS-low versus OTOS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOS→partner) and Y-score (partner→OTOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL104P →	+0.067	+3.385	<.001	.004	3	2
COAD	FAM242E →	+0.034	+7.741	<.001	.009	3	2
UCEC	RNA5SP361 →	+0.232	+4.069	<.001	.008	3	2
LUSC	RNU6-77P →	+0.997	+4.984	.003	.009	3	2
SKCM	LLPHP3 →	+0.254	+3.491	.005	.002	3	1
SKCM	PIGPP2 →	+0.024	+3.897	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

RN7SL104P by OTOS expression — SKCM

Explore this box plot interactively →