OTOS

Across TCGA patient cohorts, OTOS RNA expression is significantly associated with the go_rna of many other GO terms, with 7,008 significant associations in total. STAD shows the largest number of these associations.

The most reproducible OTOS-associated GO terms across cancer lineages are Oxidative phosphorylation, ATP biosynthetic process, and Tail-anchored membrane protein insertion into ER membrane. Each is linked with OTOS in more than 9 cancer types. Because this analysis shows association rather than direction, both OTOS-to-partner and partner-to-OTOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative phosphorylation grouped by OTOS-low versus OTOS-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOS→partner) and Y-score (partner→OTOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Oxidative phosphorylation →	+0.081	+0.083	<.001	<.001	3	9
STAD	ATP biosynthetic process →	+0.075	+0.086	<.001	<.001	3	9
STAD	Tail-anchored membrane protein insertion into ER membrane →	+0.065	+0.058	<.001	<.001	3	9
STAD	Nucleoside monophosphate biosynthetic process →	+0.059	+0.049	<.001	<.001	3	9
STAD	Ribonucleoside monophosphate biosynthetic process →	+0.062	+0.059	<.001	<.001	3	9
THYM	Ganglion development →	+0.072	+0.586	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,008 associations by consensus.

Oxidative phosphorylation by OTOS expression — STAD

Explore this box plot interactively →