Q-omics provides the consensus-scored OSR1 profile across patient tissues and cancer cell-line models. OSR1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, OSR1 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, OSR1 RNA expression shows 16,305 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight READ, COAD, and GBM as cancer lineages where OSR1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OSR1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OSR1 survival associations across molecular data types. OSR1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OSR1 RNA expression–survival associations across cancer types. High OSR1 expression shows unfavorable associations in READ, LGG and BLCA, but favorable associations in HNSC, UCS and BRCA. The READ Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify READ as the clearest survival context for OSR1 RNA expression.
This table summarizes OSR1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for OSR1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OSR1 shows lower tumor expression in COAD, THCA, LUAD and BLCA and higher tumor expression in LIHC and KIRP. The COAD box plot shows higher OSR1 RNA expression in normal versus tumor tissue (log2 FC = −1.474, t-test p < 0.001).
This table shows molecular features associated with OSR1 in patient tissues and cancer cell lines. In patient samples, OSR1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, OSR1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
