OSR1

Across TCGA pan-cancer cohorts, OSR1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated OSR1 data layer compared with 3 for mutation status.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher OSR1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OSR1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

READ, HNSC, and LGG are the cancer types where OSR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.489	0.791	<.001	88	view →
HNSC	DFS	Quartile	III,IV	0.790	0.564	<.001	72	view →
LGG	DFS	Median	All	0.289	0.487	<.001	37	view →
UCS	DFS	Tertile	II,III,IV	0.494	0.131	.012	32	view →
BRCA	OS	Tertile	All	0.613	0.515	.003	28	view →
BLCA	OS	Median	III,IV	0.276	0.602	<.001	26	view →
OV	OS	Quartile	All	0.631	0.740	.016	16	view →
ACC	OS	Tertile	II,III,IV	0.638	0.956	.009	16	view →
MESO	OS	Tertile	IV	0.703	0.182	.013	15	view →
KIRC	OS	Quartile	All	0.804	0.905	.022	14	view →
LIHC	DFS	Median	All	0.477	0.624	.003	13	view →
SCLC	OS	Median	All	0.406	0.127	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

OSR1–READ (OS)

Open the READ breakdown →