OSR1

Across TCGA cell cohorts, OSR1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OSR1-associated genes across cancer lineages are KRTAP9-2, MYF5, and MYOD1. Each is linked with OSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSR1-to-partner and partner-to-OSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP9-2 grouped by OSR1-low versus OSR1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSR1→partner) and Y-score (partner→OSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP9-2 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Leukemia	MYF5 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MYOD1 →	+0.025	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.049	+4.047	<.001	<.001	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRTAP9-2 by OSR1 expression — BLOOD_Lymphoma

Explore this box plot interactively →