Q-omics provides the consensus-scored OLAH profile across patient tissues and cancer cell-line models. OLAH expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, OLAH is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, OLAH RNA expression shows 13,482 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, and THYM as cancer lineages where OLAH shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OLAH — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OLAH survival associations across molecular data types. OLAH RNA expression shows survival associations in the most cancer types (20), followed by mutation status (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OLAH RNA expression–survival associations across cancer types. High OLAH expression shows unfavorable associations in KIRC, LUSC, UCEC, ACC and KIRP, but favorable associations in THYM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for OLAH RNA expression.
This table summarizes OLAH tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for OLAH. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OLAH shows lower tumor expression in KIRC, KICH, BRCA, LUAD and LUSC and higher tumor expression in THCA. The KIRC box plot shows higher OLAH RNA expression in normal versus tumor tissue (log2 FC = −0.400, t-test p < 0.001).
This table shows molecular features associated with OLAH in patient tissues and cancer cell lines. In patient samples, OLAH shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, OLAH RNA and mutation anchors are most strongly linked to RNA-expression features, especially in STOMACH, while CRISPR and shRNA rows add functional-dependency signals in SKIN and OVARY.
