OLAH

Across TCGA patient cohorts, OLAH mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLAH-associated genes across cancer lineages are Myosin-IIa_pS1943, p38-MAPK_pT180_Y182, and EGFR. Each is linked with OLAH in more than 1 cancer types. Because this analysis shows association rather than direction, both OLAH-to-partner and partner-to-OLAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by OLAH-low versus OLAH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLAH→partner) and Y-score (partner→OLAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.162	+1.598	.045	.022	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.486	-2.489	.005	.002	3	2
UCEC	EGFR →	-0.209	-2.000	<.001	.010	3	1
UCEC	A-Raf_pS299 →	-0.130	-2.584	.005	.010	3	1
UCEC	FASN →	+0.333	+2.000	.031	.030	3	1
UCEC	FoxM1 →	+0.306	+2.502	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Myosin-IIa_pS1943 by OLAH expression — UCEC

Explore this box plot interactively →