OLAH

Across TCGA cell cohorts, OLAH mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OLAH-associated genes across cancer lineages are ASB17, HSF5, and C12orf40. Each is linked with OLAH in more than 1 cancer types. Because this analysis shows association rather than direction, both OLAH-to-partner and partner-to-OLAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by OLAH-low versus OLAH-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLAH→partner) and Y-score (partner→OLAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	HSF5 →	+0.006	+4.029	<.001	.009	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	FAM47A →	+0.073	+4.734	<.001	.002	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1
LARGE_INTESTINE	OLIG1 →	+0.124	+3.453	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ASB17 by OLAH expression — OVARY

Explore this box plot interactively →