OLAH

Across TCGA cell cohorts, OLAH RNA expression is significantly associated with the go_rna of many other GO terms, with 646 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OLAH-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, Protein exit from endoplasmic reticulum, and Endoplasmic reticulum to cytosol transport. Each is linked with OLAH in more than 6 cancer types. Because this analysis shows association rather than direction, both OLAH-to-partner and partner-to-OLAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress grouped by OLAH-low versus OLAH-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OLAH→partner) and Y-score (partner→OLAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.112	+0.112	.003	.005	2	7
BLOOD_Lymphoma	Protein exit from endoplasmic reticulum →	+0.089	+0.655	<.001	.009	3	6
BLOOD_Lymphoma	Endoplasmic reticulum to cytosol transport →	+0.094	+0.765	<.001	.002	3	5
BLOOD_Lymphoma	Retrograde protein transport, ER to cytosol →	+0.094	+0.765	<.001	.002	3	5
SKIN	Regulation of peptidyl-serine phosphorylation of STAT protein →	+0.126	+0.221	<.001	<.001	3	5
BLOOD_Myeloma	Medium-chain fatty acid biosynthetic process →	-0.138	-0.921	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 646 associations by consensus.

Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress by OLAH expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →