N-deacetylase and N-sulfotransferase 2Genealiases: HSST2 · N-HSST 2 · NST2
Q-omics provides the consensus-scored NDST2 profile across patient tissues and cancer cell-line models. NDST2 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, NDST2 is differentially expressed in 8, with the highest sampling consensus in KIRC. Additionally, NDST2 RNA expression shows 19,691 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight ACC, KIRC, and UVM as cancer lineages where NDST2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NDST2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NDST2 survival associations across molecular data types. NDST2 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (8) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NDST2 RNA expression–survival associations across cancer types. High NDST2 expression shows unfavorable associations in ACC and LIHC, but favorable associations in SKCM, LUAD, UCS and SCLC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for NDST2 RNA expression.
This table summarizes NDST2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 2. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for NDST2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NDST2 shows lower tumor expression in KICH and LUSC and higher tumor expression in KIRC, LIHC, CHOL and STAD. The KIRC box plot shows higher NDST2 RNA expression in tumor versus normal tissue (log2 FC = +0.393, t-test p < 0.001).
This table shows molecular features associated with NDST2 in patient tissues and cancer cell lines. In patient samples, NDST2 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, NDST2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in BREAST and UPPER_AERODIGESTIVE_TRACT.
