Q-omics provides the consensus-scored MPND profile across patient tissues and cancer cell-line models. MPND expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MPND is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, MPND RNA expression shows 18,093 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, and ACC as cancer lineages where MPND shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MPND — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MPND survival associations across molecular data types. MPND RNA expression shows survival associations in the most cancer types (26), followed by mutation status (3) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MPND RNA expression–survival associations across cancer types. High MPND expression shows unfavorable associations in KICH, but favorable associations in KIRC, STAD, KIRP, UCEC and HNSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for MPND RNA expression.
This table summarizes MPND tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MPND. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MPND shows lower tumor expression in COAD and READ and higher tumor expression in KIRC, LIHC, THCA and BRCA. The KIRC box plot shows higher MPND RNA expression in tumor versus normal tissue (log2 FC = +0.470, t-test p < 0.001).
This table shows molecular features associated with MPND in patient tissues and cancer cell lines. In patient samples, MPND shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, MPND RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BONE.
