MPND

Across TCGA cell cohorts, MPND RNA expression is significantly associated with the go_rna of many other GO terms, with 4,079 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MPND-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Copper ion export, and Response to nitrosative stress. Each is linked with MPND in more than 10 cancer types. Because this analysis shows association rather than direction, both MPND-to-partner and partner-to-MPND results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by MPND-low versus MPND-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPND→partner) and Y-score (partner→MPND) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.157	+0.870	<.001	.002	3	11
KIDNEY	Copper ion export →	-0.144	-0.872	<.001	<.001	3	11
BONE	Response to nitrosative stress →	-0.176	-0.938	<.001	<.001	3	11
LUNG_SCLC	Negative regulation of protein localization to chromatin →	+0.129	+1.052	<.001	.001	3	10
LUNG_SCLC	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.182	+0.906	<.001	.001	3	10
BONE	Base-excision repair, gap-filling →	+0.109	+0.837	.003	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,079 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by MPND expression — LUNG_SCLC

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