motor neuron and pancreas homeobox 1Genealiases: HB9 · HLXB9 · HOXHB9 · SCRA1
Q-omics provides the consensus-scored MNX1 profile across patient tissues and cancer cell-line models. MNX1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, MNX1 is differentially expressed in 17, with the highest sampling consensus in KIRP. Additionally, MNX1 protein abundance shows 20,533 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, KIRP, and LSCC as cancer lineages where MNX1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MNX1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MNX1 survival associations across molecular data types. MNX1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (6) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MNX1 RNA expression–survival associations across cancer types. High MNX1 expression shows unfavorable associations in KIRC, KIRP, THCA, LUAD and UVM, but favorable associations in STAD. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for MNX1 RNA expression.
This table summarizes MNX1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for MNX1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MNX1 shows higher tumor expression in KIRP, KIRC, HNSC, BLCA, COAD and STAD. The KIRP box plot shows higher MNX1 RNA expression in tumor versus normal tissue (log2 FC = +1.790, t-test p < 0.001).
This table shows molecular features associated with MNX1 in patient tissues and cancer cell lines. In patient samples, MNX1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, MNX1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_SCLC and BREAST.
